More Effective Targeting of Tumor Angiogenesis
نویسندگان
چکیده
منابع مشابه
Nanotechnology-mediated targeting of tumor angiogenesis
Angiogenesis is disregulated in many diseased states, most notably in cancer. An emerging strategy for the development of therapies targeting tumor-associated angiogenesis is to harness the potential of nanotechnology to improve the pharmacology of chemotherapeutics, including anti-angiogenic agents. Nanoparticles confer several advantages over that of free drugs, including their capability to ...
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Tumorigenesis is a complex multistep process involving not only genetic and epigenetic changes in the tumor cell but also selective supportive conditions of the deregulated tumor microenvironment. One key compartment of the microenvironment is the vascular niche. The role of angiogenesis in solid tumors but also in hematologic malignancies is now well established. Research on angiogenesis in ge...
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Whereas nascent tumors fulfill their metabolic requirements for oxygen and nutrients through diffusion from the existing vasculature, advanced lesions engender the formation of new blood vessels to support progressive tumor growth and to effectuate tissue invasion and metastasis (1). Angiogenesis reflects the complex interplay of multiple cell types, whose functions are orchestrated by an array...
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Solid tumors are dependent on preexisting vasculature and neovascularization for their growth. Successful cancer therapies targeting the tumor vasculature would be expected to block the existing tumor blood supply and to prevent tumor neovascularization. We tested the antitumor activity of experimental therapy with 2 distinct antiangiogenic drugs. Vasostatin inhibits endothelial cell growth and...
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ژورنال
عنوان ژورنال: Neurosurgery
سال: 2004
ISSN: 0148-396X,1524-4040
DOI: 10.1227/01.neu.0000309632.23725.c7